Podcast / Episode 19 - Wayne & Mary's
Episode 19 - Dialed In Health

55 Years in Supplements: The 5 We Take Daily and the Magnesium Mistake Everyone Makes

Magnesium Glycinate Vitamin D3 + K2 Creatine for Women Fish Oil Probiotics DSHEA / FDA June 2, 2026 - 63 min

With Andrew Reinartz and Rosanne Reinartz (Co-Owners) — Wayne & Mary's Nutrition Center · Sioux Falls, SD

Episode Chapters
Key Takeaways

"Your health is not a click. It is a conversation. The right supplement is the one matched to your diet, your medications, your sleep, your goals — not the one with the loudest marketing."

— The Wayne & Mary's philosophy

"Magnesium oxide is what most doctors recommend. It is also the most poorly absorbed form. If you are taking magnesium for sleep, stress, or muscle relaxation and feeling nothing, the form is likely the reason."

— On the magnesium mistake

"D3 alone in high doses, without K2, is one of the things we steer people away from. D3 pulls calcium into the blood. K2 directs it into bone instead of the artery wall."

— The D3 + K2 pairing

"Creatine is no longer a lifter's supplement. For women going through perimenopause and menopause, three to five grams of monohydrate a day is foundational, not optional."

— On creatine for women

"Leafy greens have lost about 80 percent of their mineral content since 1914. Even a careful diet is not what the old nutrition charts describe. That is part of why basic supplementation matters more now than it did a generation ago."

— The Syracuse study
Questions Answered
What supplements should adults take daily?

After 55 years running a nutrition center, Andrew and Rosanne Reinartz of Wayne and Mary's recommend 5 daily basics for most adults: a quality multivitamin, fish oil for omega 3, vitamin D3 paired with K2, a probiotic, and magnesium (glycinate form preferred for absorption). The right specific brand depends on a conversation about your current diet, medications, sleep, energy, and goals, which is why an in-store consultation matters more than a label.

What is the difference between magnesium glycinate, oxide, citrate, and L-threonate?

Magnesium oxide is the most common form in medical settings but is poorly absorbed and works mainly as a laxative. Magnesium citrate is better absorbed and still has a mild laxative effect, useful for occasional constipation. Magnesium glycinate, bound to the calming amino acid glycine, is the most absorbable form and is preferred for sleep, muscle relaxation, anxiety, and stress. Magnesium L-threonate is the only form that crosses the blood brain barrier well and is used for cognitive support and memory.

Why does vitamin D3 need to be taken with K2?

Vitamin D3 pulls calcium from the digestive tract into the bloodstream. Vitamin K2 (specifically the MK7 form) then directs that calcium into the bones and teeth instead of letting it deposit in soft tissue and the vascular system. Taking D3 alone in high doses without K2 can contribute to arterial calcification, which is why most quality D3 products today are formulated with K2 already included.

Are supplements regulated by the FDA?

Yes. Under the Dietary Supplement Health and Education Act of 1994, known as DSHEA, the FDA regulates supplement manufacturing, labeling, marketing, and safety. Supplements are not regulated like prescription drugs. They are treated as a subcategory of food and are subject to current good manufacturing processes (C-GMP), required adverse event reporting, and FDA inspections. Reputable brands also carry third party testing certifications like NSF or USP that go beyond the FDA requirement.

Should women take creatine?

Yes. Women have lower natural creatine stores than men and tend to consume less through diet because creatine comes primarily from red meat. Supplementing with creatine monohydrate at 3 to 5 grams daily supports muscle mass, bone density, brain function, and recovery, especially through perimenopause and menopause when estrogen decline makes maintaining muscle and bone harder. Creatine is one of the most studied supplements in existence and is now considered foundational, not optional, for women over 40.

What should I look for on a supplement label?

Four things. First, third party testing certifications from NSF or USP. Second, the amount of active ingredient per serving (not per bottle, per serving). Third, the serving size, because some products require four capsules to deliver one effective dose. Fourth, the other ingredients list. Watch for unnecessary dyes, sugars, fillers, and proprietary blends that hide the actual amounts. Anything unclear on a label is a red flag.

Do probiotics really need to be refrigerated?

Not always. The refrigeration rule applies to certain strains and certain formulations, not to all probiotics. Modern shelf stable probiotics use protective casings and freeze dried strains that survive room temperature storage and the trip through stomach acid. What matters more is strain diversity, CFU count at end of shelf life (not at manufacture), and that the strains have actual research behind them.

Where can I get a free supplement consultation in Sioux Falls?

Wayne & Mary's Nutrition Center offers free in-store consultations at both locations: 41st & Kiwanis and 26th & Sycamore. Hours are Monday through Friday 9 to 6, Saturday 9 to 5. Phone and mail orders are also available. Visit waynemarys.com for more, or find the full Wayne & Mary's listing on the Dialed In Health Directory.

Myth Busters
Myth: Supplements are not FDA regulated, so anything goes.
Reality: Under DSHEA 1994, the FDA regulates supplement manufacturing, labeling, marketing, and safety. The pathway is different from prescription drugs, but oversight exists. Reputable brands add NSF or USP third-party certifications on top.
Myth: Magnesium is magnesium. The form does not matter.
Reality: Oxide is poorly absorbed and mostly a laxative. Citrate is better and still mildly laxative. Glycinate is the most absorbable and is preferred for sleep and stress. L-threonate crosses the blood brain barrier for cognitive support. The form matters more than the dose on the label.
Myth: I eat a clean diet, so I do not need supplements.
Reality: A great diet is the foundation. But the Syracuse study showed leafy greens have lost 80 percent of their mineral content since 1914 due to soil depletion. Even a careful diet may not deliver what older charts suggest.
Myth: Creatine is just for bodybuilders.
Reality: Creatine is one of the most studied supplements in existence. It supports muscle, bone density, brain function, and recovery. Women, who have lower natural stores and consume less from diet, may benefit even more than men.
Myth: Probiotics have to be refrigerated.
Reality: Most modern shelf stable probiotics use protective casings and freeze-dried strains that survive room temperature storage and stomach acid. What matters is strain diversity, CFU count at end of shelf life, and research-backed strains.
Myth: You can take vitamin D3 in high doses safely without K2.
Reality: D3 pulls calcium into the bloodstream. Without K2 to direct that calcium into bone, it can deposit in soft tissue and arteries. Pair them, or buy a formula that has both.
About This Episode

Most people stand in front of a wall of supplements with no idea what they actually need. After 55 years running Wayne & Mary's Nutrition Center in Sioux Falls, Andrew and Rosanne Reinartz have built the opposite of that experience. Their philosophy is short and impossible to unhear: your health is not a click, it is a conversation.

In this episode, Andrew and Rosanne walk through the 5 supplements most adults actually need every day, why magnesium glycinate beats magnesium oxide (the form your doctor probably recommended), why vitamin D3 needs K2 to direct calcium into bone instead of arteries, the truth about whether the FDA regulates supplements (yes, under DSHEA 1994), how to read a supplement label like a pro, and why creatine is now considered foundational for women, not just lifters.

Wayne & Mary's Nutrition Center is a family-run natural health store founded in Sioux Falls in 1970 by Wayne Pitts, who started the business after managing MS symptoms with nutrition and supplementation. Two locations: 41st & Kiwanis and 26th & Sycamore. In-store consultations are free. Phone and mail orders available. Practitioner-grade supplements and partnerships with functional medicine providers across the region.

Topics covered: the 5 daily supplements most adults are missing, magnesium glycinate vs oxide vs citrate vs L-threonate, why D3 needs K2 (MK7), the DSHEA 1994 truth on FDA regulation, how to read a supplement label, third-party testing (NSF, USP, C-GMP), creatine for women in perimenopause and menopause, the probiotic refrigeration myth, and the Syracuse study on 80 percent mineral loss since 1914.