Best Functional Medicine in Sioux Falls: 2026 Guide
A vetted look at the functional medicine clinics serving Sioux Falls and the broader region, ranked by editorial review, Google rating, and patient review volume.
Sioux Falls has eight functional medicine providers active on the Dialed In Health directory, ranging from MD-led primary care clinics with full root-cause workups to peptide and longevity-focused clinics. This guide ranks them, explains who each one is the best fit for, and tells you what to ask before you book.
The directory is independently reviewed before any provider is listed. Featured Providers (Radiant Health and Hormone Therapy, and Prairie Roots Health) are paid editorial partners; that relationship is disclosed at the top of their entries. All other rankings come from a transparent composite score that pulls from Google rating, Google review volume, podcast appearance, and the depth of services the provider lists. The full formula sits at the bottom of this guide.
Featured Providers
Radiant Health and Hormone Therapy
Radiant Health is a functional medicine clinic built around hormone optimization for women in perimenopause and menopause, men in TRT, and patients dealing with thyroid, gut, and adrenal patterns that conventional care has missed. The clinic also runs the body sculpting and pelvic floor side (EMSELLA, EMSCULPT, EMFACE) and combines acupuncture with the functional workup. Uncommon for a clinic in this region.
- Address: 4928 E Rosa Parks Pl, Sioux Falls, SD 57110
- Phone: (605) 604-0200
- Google rating: (9 reviews)
Prairie Roots Health
Prairie Roots is the only MD-led, direct primary care clinic on the directory that pairs full functional medicine workups with chiropractic, prenatal and postpartum care, doula support, and pediatric and family wellness, all under one roof. The DPC model means you pay a flat monthly membership and skip the insurance maze for primary care visits, with functional workups available as add-ons. They serve patients across South Dakota and Minnesota virtually.
- Address: 2333 W 57th St Ste 103, Sioux Falls, SD
- Phone: (605) 271-5640
- Website: prairierootshealth.com
- Google rating: (70 reviews)
Other Top-Rated Functional Medicine Providers in Sioux Falls
Vitalis MVMT + Wellness
A Harrisburg-based clinic that combines functional medicine with peptide therapy (BPC-157, TB-500), GLP-1 weight loss support (semaglutide, tirzepatide), hormone optimization, IV therapy and NAD+, and aesthetics. Strong fit for patients interested in peptide protocols alongside the standard functional workup.
- Address: 220 S Cliff Ave Ste 126, Harrisburg, SD 57032
- Phone: (605) 767-1601
- Website: vitaliswellness.life
- Google rating: (29 reviews)
Accelerate Wellness
A functional and regenerative medicine clinic focused on longevity protocols: peptides, hormone optimization, and recovery work. Suited to patients who want a performance and longevity lens on the functional workup, not just symptom resolution.
- Address: 5201 E 57th St, Sioux Falls, SD 57108
- Phone: (605) 231-9505
- Website: acceleratemywellness.com
- Google rating: (46 reviews)
Revive Functional Medicine
A functional medicine practice that pairs root-cause workups with IV therapy: Myers' cocktails, vitamin and mineral infusions, and recovery drips. Centrally located on West 39th Street.
- Address: 115 W 39th St, Sioux Falls, SD 57105
- Google rating:
Mary Wuebben Wellness
A solo functional medicine practice serving the Sioux Falls area. Focus on individualized workups for patients with chronic, unexplained, or recurrent issues.
- Website: marywuebbenwellness.com
- Google rating:
Functional Health Clinic SD
A functional medicine clinic on West 41st Street offering individualized workups for chronic conditions.
- Address: 2101 W 41st St Ste 113, Sioux Falls, SD 57105
- Phone: (605) 201-4632
- Website: functionalhealthsd.com
- Google rating:
Peakform Wellness Clinic
A functional medicine practice with a sports performance and recovery focus. Often a fit for active patients and athletes wanting a functional lens on training, recovery, and longevity.
- Address: 2333 W 57th St Ste 102, Sioux Falls, SD 57108
- Phone: (605) 368-6209
Featured on the Dialed In Health Podcast
The functional medicine conversation on the podcast has covered hormones, environmental disruptors, and the gap between primary care and root-cause work. Episodes you may want next:
Episode 10
Your Couch & Makeup Are Wrecking Your Hormones
Radiant Health on environmental hormone disruptors, BHRT, and the missing hormone most women don't hear about until midlife.
Episode 05
HRT & the Missing Hormone Most Women Don't Know
A deep dive on hormones, HRT, and the hormone most women's doctors leave out.
Episode 06
Cortisol & Stress
Why cortisol is the under-recognized driver behind most modern symptom patterns.
Frequently Asked Questions
Who is the best functional medicine clinic in Sioux Falls?
Based on Featured Provider status, Google review scores, podcast appearance, and editorial review, Radiant Health and Hormone Therapy ranks first on the Dialed In Health directory for Sioux Falls functional medicine. Their 5.0-star Google rating, Episode 10 appearance, and breadth of services across hormones, thyroid, gut, acupuncture, and aesthetics put them at the top. Prairie Roots Health is a close second and the strongest fit if you want functional medicine paired with direct primary care under one MD-led roof. The directory currently lists eight functional medicine providers serving Sioux Falls.
How is functional medicine different from primary care?
Primary care is built around screening, prevention, and managing common conditions inside the insurance model. Typically 15-minute visits, lab panels driven by guideline thresholds, and prescriptions when indicated. Functional medicine spends most of its time on the why: looking at gut, hormone, immune, metabolic, and environmental drivers behind symptoms, often with broader lab panels, longer initial visits, and lifestyle and supplement interventions alongside (or instead of) medication. Many Sioux Falls patients use both: primary care for screening and acute issues, functional medicine for chronic patterns that haven't resolved.
How much does functional medicine cost in Sioux Falls?
It varies. Most functional medicine clinics in the region price initial workups between $300 and $800, follow-ups between $150 and $400, and lab panels separately ($200 to $1,500 depending on what's ordered). Direct primary care clinics like Prairie Roots Health charge a flat monthly membership for primary care visits, with functional workups available as add-ons. Insurance coverage is limited and varies; most functional clinics do not bill insurance directly but will provide a superbill you can submit yourself.
What should I look for in a functional medicine provider in Sioux Falls?
Four things. First, training: look for board certification in family medicine, internal medicine, or a related specialty plus additional functional or IFM training. Second, lab philosophy: ask how they decide which labs to run and whether they explain results in a way you can understand. Third, scope: clinics that focus on hormones differ from clinics that focus on gut or autoimmunity, so match the clinic to your situation. Fourth, transparency on cost: ask for the full price of the initial workup, follow-ups, and labs before you commit.
Does insurance cover functional medicine in Sioux Falls?
Generally no for the functional workup itself. Most functional medicine clinics in the region are out-of-network or cash-pay. Labs may be billable to insurance if ordered through a network lab. Direct primary care memberships are typically out-of-pocket but can be paired with a high-deductible insurance plan. Always confirm coverage directly with the clinic and your insurer before your first visit.
How does Dialed In Health choose functional medicine providers?
Every provider on the Dialed In Health directory is independently reviewed before listing. We verify business details, scope of practice, licensure where applicable, and Google review scores. Featured Provider placements are paid editorial partnerships, clearly disclosed at the top of their entries. Within each tier, providers are ranked by a composite score of Google ratings, review volumes, podcast appearances, and similar editorial signals. Rankings refresh annually.
How we ranked these providers
Eight functional medicine providers were reviewed for this guide, covering Sioux Falls and providers serving the Sioux Falls metro virtually from South Dakota and Minnesota. Featured Providers (Radiant Health and Hormone Therapy, Prairie Roots Health) are paid editorial partners on Dialed In Health and are surfaced first. That relationship is disclosed at the top of their section.
All other providers are ranked by a composite score of Google ratings, review volumes, podcast appearances, and similar editorial signals. We do not accept payment to alter rankings within a tier.
This guide was last reviewed June 1, 2026 and will be refreshed annually.
Browse the Full Directory
The Dialed In Health directory lists every functional medicine provider currently active in the region.
See all functional medicine providers →